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MMP12 Antibody

CAT: 0223-62-169Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-62-169Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP12 may be involved in tissue injury and remodeling. This protein has significant elastolytic activity. MMP12 can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, wtih small hydrophobic residues (prefereably alanine) occupying P3. The protein is found in alveolar macrophages but not in peripheral blood monocytes. MMP12 can be induced by exposure to lypopolysaccharide, and is inhibited by dexamethasone.
NCBI Gene ID
4321
Swiss Prot
P39900
Accession Number
P39900
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This MMP12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-420 amino acids from the C-terminal region of human MMP12.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
54 kDa
Fragment
Rabbit Ig
Symbol
MMP12
NCBI Official Name
Macrophage metalloelastase
NCBI Organism
Homo sapiens
Background Reference 01
Nar, H., et al., J. Mol. Biol. 312 (4) :743-751 (2001) .
Background Reference 02
Lang, R., et al., J. Mol. Biol. 312 (4) :731-742 (2001) .
Background Reference 03
Gronski, T.J. Jr., et al., J. Biol. Chem. 272 (18) :12189-12194 (1997) .
Background Reference 04
Shapiro, S.D., et al., J. Biol. Chem. 268 (32) :23824-23829 (1993) .
Other Product Names
Macrophage metalloelastase, MME, Macrophage elastase, ME, hME, Matrix metalloproteinase-12, MMP-12, MMP12, HME
Tested Applications
WB, IHC-P, IF
Protein ID
729179
Physical Properties
Liquid

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