MMP12 Antibody

• Background:

  Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP12 may be involved in tissue injury and remodeling. This protein has significant elastolytic activity. MMP12 can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, wtih small hydrophobic residues (prefereably alanine) occupying P3. The protein is found in alveolar macrophages but not in peripheral blood monocytes. MMP12 can be induced by exposure to lypopolysaccharide, and is inhibited by dexamethasone.

• NCBI Gene ID:

  4321

• Swiss Prot:

  P39900

• Accession Number:

  P39900

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This MMP12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-420 amino acids from the C-terminal region of human MMP12.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  54 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  MMP12

• NCBI Official Name:

  Macrophage metalloelastase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Nar, H., et al., J. Mol. Biol. 312 (4) :743-751 (2001) .

• Background Reference 02:

  Lang, R., et al., J. Mol. Biol. 312 (4) :731-742 (2001) .

• Background Reference 03:

  Gronski, T.J. Jr., et al., J. Biol. Chem. 272 (18) :12189-12194 (1997) .

• Background Reference 04:

  Shapiro, S.D., et al., J. Biol. Chem. 268 (32) :23824-23829 (1993) .

• Other Product Names:

  Macrophage metalloelastase, MME, Macrophage elastase, ME, hME, Matrix metalloproteinase-12, MMP-12, MMP12, HME

• Tested Applications:

  WB, IHC-P, IF

• Protein ID:

  729179

• Physical Properties:

  Liquid