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MLLT1 Antibody

CAT: 0223-62-162Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-62-162Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Chromosome band 11q23 is the site of translocations in myeloid and lymphoid acute leukemias, pediatric leukemias, and treatment-induced secondary acute myelogenous leukemia. The translocation breakpoints cluster in a restricted region of the HRX gene resulting in chimeric genes that encode an N-terminal portion of Hrx fused to various partner proteins. Myeloid/lymphoid or mixed-lineage leukemia translocated to 1 (MLLT1) is a nuclear protein with transcriptional transactivation properties that is fused to Hrx in t (11;19) leukemias. The minimal MLLT1 sequence required for transcription activation was narrowed to the C-terminal 90 amino acids.
NCBI Gene ID
4298
Swiss Prot
Q03111
Accession Number
Q03111
Host
Rabbit
Reactivity
Human
Immunogen
This MLLT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 523-552 amino acids from the C-terminal region of human MLLT1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
62 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:2000
Symbol
MLLT1
NCBI Official Name
Protein ENL
NCBI Organism
Homo sapiens
Background Reference 01
Nie, Z., et al., Mol. Cell. Biol. 23 (8) :2942-2952 (2003) .
Background Reference 02
Lavau, C., et al., Proc. Natl. Acad. Sci. U.S.A. 97 (20) :10984-10989 (2000) .
Background Reference 03
Thirman, M.J., et al., Proc. Natl. Acad. Sci. U.S.A. 91 (25) :12110-12114 (1994) .
Background Reference 04
Rubnitz, J.E., et al., Blood 84 (6) :1747-1752 (1994) .
Other Product Names
Protein ENL, YEATS domain-containing protein 1, MLLT1, ENL, LTG19, YEATS1
Tested Applications
WB
Protein ID
116241350
Physical Properties
Liquid

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