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Leptin Receptor Antibody

CAT: 0223-62-143Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-62-143Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Leptin, an adipocyte-specific hormone, regulates adipose-tissue mass through hypothalamic effects on satiety and energy expenditure by acting through the leptin receptor (LEPR) . LEPR is a single-transmembrane-domain receptor of the cytokine receptor family that is identical to the mouse diabetes (db) gene product. During weight loss, leptin levels decrease, whereas soluble LEPR levels and the receptor bound fraction of leptin increases. The presence of LEPR in the absorptive cells of the small intestine suggests that leptin may have a physiological role in the regulation of nutrient absorption.
NCBI Gene ID
3953
Swiss Prot
P48357
Accession Number
P48357
Host
Rabbit
Reactivity
Human
Immunogen
This Leptin Receptor (LEPR) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 23-52 amino acids from the N-terminal region of human Leptin Receptor (LEPR) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Neuroscience, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
132 kDa
Fragment
Rabbit Ig
Symbol
LEPR
NCBI Official Name
Leptin receptor
NCBI Organism
Homo sapiens
Background Reference 01
Schroth, M., et al., J. Clin. Endocrinol. Metab. 88 (11) :5497-5501 (2003) .
Background Reference 02
Couturier, C., et al., J. Biol. Chem. 278 (29) :26604-26611 (2003) .
Background Reference 03
Gavrila, A., et al., J. Clin. Endocrinol. Metab. 88 (6) :2838-2843 (2003) .
Background Reference 04
Yannakoulia, M., et al., J. Clin. Endocrinol. Metab. 88 (4) :1730-1736 (2003) .
Other Product Names
Leptin receptor, LEP-R, HuB219, OB receptor, OB-R, CD295, LEPR, DB, OBR
Tested Applications
WB, IHC-P, Flow
Protein ID
116242617
Physical Properties
Liquid

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