Leptin Antibody

• Background:

  Leptin (LEP) is an adipocyte-secreted protein that regulates body fat and endocrine functions. Leptin is similar to the mouse obesity protein encoded by the obese gene (ob) . In mouse studies, mutations in this gene are linked to severe and morbid obesity.

• NCBI Gene ID:

  3952

• Swiss Prot:

  P41159

• Accession Number:

  P41159

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This Leptin (LEP) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 134-166 amino acids from the C-terminal region of human Leptin (LEP) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Neuroscience, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  19 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  LEP

• NCBI Official Name:

  Leptin

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Tank, J., et al., J. Clin. Endocrinol. Metab. 88 (10) :4955-4959 (2003) .

• Background Reference 02:

  Silha, J.V., et al., Eur. J. Endocrinol. 149 (4) :331-335 (2003) .

• Background Reference 03:

  Kazumi, T., et al., Metab. Clin. Exp. 52 (9) :1113-1116 (2003) .

• Background Reference 04:

  Mullington, J.M., et al., J. Neuroendocrinol. 15 (9) :851-854 (2003) .

• Other Product Names:

  Leptin, Obese protein, Obesity factor, LEP, OB, OBS

• Tested Applications:

  WB, IF

• Physical Properties:

  Liquid