TCF4 Antibody

• Background:

  TCF4 is transcription factor 4, a basic helix-turn-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is expressed predominantly in pre-B-cells, although it is found in other tissues as well. Defects in this gene are a cause of Pitt-Hopkins syndrome.

• NCBI Gene ID:

  6925

• Swiss Prot:

  P15884

• Accession Number:

  P15884

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This TCF4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 48-73 amino acids from the N-terminal region of human TCF4.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  71 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  TCF4

• NCBI Official Name:

  Transcription factor 4

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Rosenfeld, J.A., et al. Genet. Med. 11 (11) :797-805 (2009)

• Background Reference 02:

  Herbst, A., et al. Biochem. Biophys. Res. Commun. 387 (4) :736-740 (2009)

• Background Reference 03:

  Rena, V., et al. Placenta 30 (10) :876-883 (2009)

• Background Reference 04:

  Henthorn, P., et al. Science 247 (4941) :467-470 (1990)

• Other Product Names:

  Transcription factor 4, TCF-4, Class B basic helix-loop-helix protein 19, bHLHb19, Immunoglobulin transcription factor 2, ITF-2, SL3-3 enhancer factor 2, SEF-2, TCF4, BHLHB19, ITF2, SEF2

• Tested Applications:

  WB, Flow

• Physical Properties:

  Liquid