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AVP Antibody

CAT: 0223-61-973Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-61-973Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a precursor protein consisting of arginine vasopressin and two associated proteins, neurophysin 2 and a glycopeptide, copeptin. Arginine vasopressin is a posterior pituitary hormone which is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin 2, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. The precursor is thought to be activated while it is being transported along the axon to the posterior pituitary. Arginine vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. It has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. This hormone can contract smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions.
NCBI Gene ID
551
Swiss Prot
P01185
Accession Number
P01185
Host
Rabbit
Reactivity
Human
Immunogen
This AVP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 102-129 amino acids from the Central region of human AVP.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
17 kDa
Fragment
Rabbit Ig
Symbol
AVP
NCBI Official Name
Vasopressin-neurophysin 2-copeptin
NCBI Organism
Homo sapiens
Background Reference 01
Abu Libdeh, A., et al. Eur. J. Endocrinol. 162 (2) :221-226 (2010)
Background Reference 02
Cirillo, M. Kidney Int. 77 (1) :5-6 (2010)
Background Reference 03
Meijer, E., et al. Kidney Int. 77 (1) :29-36 (2010)
Background Reference 04
Birk, J., et al. J. Cell. Sci. 122 (PT 21), 3994-4002 (2009)
Other Product Names
Vasopressin-neurophysin 2-copeptin, AVP-NPII, Arg-vasopressin, Arginine-vasopressin, Neurophysin 2, Neurophysin-II, Copeptin, AVP, ARVP, VP
Tested Applications
WB, IHC-P, IF
Protein ID
128083
Physical Properties
Liquid

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