PMCH Antibody

• Background :

  The melanin-concentrating hormone (MCH) is a cyclic neuropeptide isolated initially from salmon pituitary gland and later from rat hypothalamus (summarized by Nahon et al., 1992 [PubMed 1572663]) . In mammals, MCH perikarya are confined largely to the lateral hypothalamus and zona incerta area with extensive neuronal projections throughout the brain, including the neurohypophysis. The anatomic distribution suggests a neurotransmitter or neuromodulator role for MCH in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. MCH and 2 other putative neuropeptides, NEI and NGE, are encoded by the same precursor and appear colocalized in nerve cells and in many instances within the projections. The precursor is designated pro-melanin-concentrating hormone (PMCH) .

• NCBI Gene ID :

  5367

• Swiss Prot :

  P20382

• Accession Number :

  P20382

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Immunogen :

  This PMCH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 94-122 amino acids from the Central region of human PMCH.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Neuroscience, Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  19 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  PMCH

• NCBI Official Name :

  Pro-MCH

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Kim, J.J., et al. J. Hum. Genet. 55 (1) :27-31 (2010)

• Background Reference 02 :

  Gratacos, M., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :

• Background Reference 03 :

  Aziz, A., et al. Brain Pathol. 18 (4) :474-483 (2008)

• Background Reference 04 :

  Kokkotou, E., et al. Proc. Natl. Acad. Sci. U.S.A. 105 (30) :10613-10618 (2008)

• Other Product Names :

  Pro-MCH, Neuropeptide-glycine-glutamic acid, NGE, Neuropeptide G-E, Neuropeptide-glutamic acid-isoleucine, NEI, Neuropeptide E-I, Melanin-concentrating hormone, MCH, PMCH, MCH

• Tested Applications :

  WB, IHC-P, Flow

• Protein ID :

  229462960

• Physical Properties :

  Liquid