PMCH Antibody

• Background:

  The melanin-concentrating hormone (MCH) is a cyclic neuropeptide isolated initially from salmon pituitary gland and later from rat hypothalamus (summarized by Nahon et al., 1992 [PubMed 1572663]) . In mammals, MCH perikarya are confined largely to the lateral hypothalamus and zona incerta area with extensive neuronal projections throughout the brain, including the neurohypophysis. The anatomic distribution suggests a neurotransmitter or neuromodulator role for MCH in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. MCH and 2 other putative neuropeptides, NEI and NGE, are encoded by the same precursor and appear colocalized in nerve cells and in many instances within the projections. The precursor is designated pro-melanin-concentrating hormone (PMCH) .

• NCBI Gene ID:

  5367

• Swiss Prot:

  P20382

• Accession Number:

  P20382

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This PMCH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 94-122 amino acids from the Central region of human PMCH.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  19 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  PMCH

• NCBI Official Name:

  Pro-MCH

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kim, J.J., et al. J. Hum. Genet. 55 (1) :27-31 (2010)

• Background Reference 02:

  Gratacos, M., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :

• Background Reference 03:

  Aziz, A., et al. Brain Pathol. 18 (4) :474-483 (2008)

• Background Reference 04:

  Kokkotou, E., et al. Proc. Natl. Acad. Sci. U.S.A. 105 (30) :10613-10618 (2008)

• Other Product Names:

  Pro-MCH, Neuropeptide-glycine-glutamic acid, NGE, Neuropeptide G-E, Neuropeptide-glutamic acid-isoleucine, NEI, Neuropeptide E-I, Melanin-concentrating hormone, MCH, PMCH, MCH

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  229462960

• Physical Properties:

  Liquid