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PMCH Antibody

CAT: 0223-61-963Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-61-963Size:400 µL
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Background
The melanin-concentrating hormone (MCH) is a cyclic neuropeptide isolated initially from salmon pituitary gland and later from rat hypothalamus (summarized by Nahon et al., 1992 [PubMed 1572663]) . In mammals, MCH perikarya are confined largely to the lateral hypothalamus and zona incerta area with extensive neuronal projections throughout the brain, including the neurohypophysis. The anatomic distribution suggests a neurotransmitter or neuromodulator role for MCH in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. MCH and 2 other putative neuropeptides, NEI and NGE, are encoded by the same precursor and appear colocalized in nerve cells and in many instances within the projections. The precursor is designated pro-melanin-concentrating hormone (PMCH) .
NCBI Gene ID
5367
Swiss Prot
P20382
Accession Number
P20382
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This PMCH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 94-122 amino acids from the Central region of human PMCH.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
19 kDa
Fragment
Rabbit Ig
Symbol
PMCH
NCBI Official Name
Pro-MCH
NCBI Organism
Homo sapiens
Background Reference 01
Kim, J.J., et al. J. Hum. Genet. 55 (1) :27-31 (2010)
Background Reference 02
Gratacos, M., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :
Background Reference 03
Aziz, A., et al. Brain Pathol. 18 (4) :474-483 (2008)
Background Reference 04
Kokkotou, E., et al. Proc. Natl. Acad. Sci. U.S.A. 105 (30) :10613-10618 (2008)
Other Product Names
Pro-MCH, Neuropeptide-glycine-glutamic acid, NGE, Neuropeptide G-E, Neuropeptide-glutamic acid-isoleucine, NEI, Neuropeptide E-I, Melanin-concentrating hormone, MCH, PMCH, MCH
Tested Applications
WB, IHC-P, Flow
Protein ID
229462960
Physical Properties
Liquid

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