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ATP6V0A4 Antibody

CAT: 0223-61-905Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-61-905Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. This gene is one of four genes in man and mouse that encode different isoforms of the a subunit. Alternatively spliced transcript variants encoding the same protein have been described. Mutations in this gene are associated with renal tubular acidosis associated with preserved hearing.
NCBI Gene ID
50617
Swiss Prot
Q9HBG4
Accession Number
Q9HBG4
Host
Rabbit
Reactivity
Human
Immunogen
This ATP6V0A4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 235-261 amino acids from the Central region of human ATP6V0A4.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
96 kDa
Fragment
Rabbit Ig
Symbol
ATP6V0A4
NCBI Official Name
V-type proton ATPase 116 kDa subunit a isoform 4
NCBI Organism
Homo sapiens
Background Reference 01
Andreucci, E., et al. Pediatr. Nephrol. 24 (11) :2147-2153 (2009)
Background Reference 02
Hinton, A., et al. J. Biol. Chem. 284 (24) :16400-16408 (2009)
Background Reference 03
Su, Y., et al. Am. J. Physiol. Renal Physiol. 295 (4), F950-F958 (2008) :
Background Reference 04
Norgett, E.E., et al. J. Biol. Chem. 282 (19) :14421-14427 (2007)
Other Product Names
V-type proton ATPase 116 kDa subunit a isoform 4, V-ATPase 116 kDa isoform a4, Vacuolar proton translocating ATPase 116 kDa subunit a isoform 4, Vacuolar proton translocating ATPase 116 kDa subunit a kidney isoform, ATP6V0A4, ATP6N1B, ATP6N2
Tested Applications
WB, Flow
Protein ID
308153516
Physical Properties
Liquid

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