TNFRSF8-Y479 Antibody

• Background:

  TNFRSF8 is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity.

• NCBI Gene ID:

  943

• Swiss Prot:

  P28908

• Accession Number:

  P28908

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This TNFRSF8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 458-487 amino acids from human TNFRSF8.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Immunology, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  64 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  TNFRSF8

• NCBI Official Name:

  Tumor necrosis factor receptor superfamily member 8

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Braun, F.K., et al. J. Invest. Dermatol. 130 (3) :826-840 (2010)

• Background Reference 02:

  Azarpira, N., et al. SaudiKidney Dis Transpl 21 (1) :31-36 (2010)

• Background Reference 03:

  Edinger, J.T., et al. Am. J. Surg. Pathol. 33 (12) :1860-1868 (2009)

• Other Product Names:

  Tumor necrosis factor receptor superfamily member 8, CD30L receptor, Ki-1 antigen, Lymphocyte activation antigen CD30, CD30, TNFRSF8, CD30, D1S166E

• Tested Applications:

  WB, IHC-P

• Protein ID:

  115978

• Physical Properties:

  Liquid