BBS10 Antibody

• Background:

  BBS10 is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by progressive retinal degeneration, obesity, polydactyly, renal malformation and mental retardation. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene is likely not a ciliary protein but rather has distant sequence homology to type II chaperonins. As a molecular chaperone, this protein may affect the folding or stability of other ciliary or basal body proteins. Inhibition of this protein's expression impairs ciliogenesis in preadipocytes.

• NCBI Gene ID:

  79738

• Swiss Prot:

  Q8TAM1

• Accession Number:

  Q8TAM1

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This BBS10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 515-544 amino acids from the C-terminal region of human BBS10.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  81 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  BBS10

• NCBI Official Name:

  Bardet-Biedl syndrome 10 protein

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Marion, V., et al. Proc. Natl. Acad. Sci. U.S.A. 106 (6) :1820-1825 (2009)

• Background Reference 02:

  Gerth, C., et al. Vision Res. 48 (3) :392-399 (2008)

• Background Reference 03:

  White, D.R., et al. Eur. J. Hum. Genet. 15 (2) :173-178 (2007)

• Other Product Names:

  Bardet-Biedl syndrome 10 protein, BBS10, C12orf58

• Tested Applications:

  WB, Flow

• Protein ID:

  97043964

• Physical Properties:

  Liquid