S6K Antibody

CAT: 0223-61-629Size: 200 µLDry Ice: NoHazardous: No
CAT#:0223-61-629Size:200 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
RPS6KB1 is a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding the gene for RPS6KB1 and overexpression of this kinase are seen in some breast cancer cell lines.
NCBI Gene ID
6198
Swiss Prot
P23443
Accession Number
P23443
Host
Rabbit
Reactivity
Human
Immunogen
This S6K (RPS6KB1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 425-454 amino acids from human S6K (RPS6KB1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Obesity, Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rabbit, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
59 kDa
Fragment
Rabbit Ig
Symbol
RPS6KB1
NCBI Official Name
Ribosomal protein S6 kinase beta-1
NCBI Organism
Homo sapiens
Background Reference 01
Adem, C., et al., Genes Chromosomes Cancer 41 (1) :1-11 (2004) .
Background Reference 02
Suzuki, Y., et al., Genome Res. 14 (9) :1711-1718 (2004) .
Background Reference 03
Gomez-Cambronero, J., et al., Leuk. Res. 28 (7) :755-762 (2004) .
Background Reference 04
Raught, B., et al., EMBO J. 23 (8) :1761-1769 (2004) .
Other Product Names
Ribosomal protein S6 kinase beta-1, S6K-beta-1, S6K1, 70 kDa ribosomal protein S6 kinase 1, P70S6K1, p70-S6K 1, Ribosomal protein S6 kinase I, Serine/threonine-protein kinase 14A, p70 ribosomal S6 kinase alpha, p70 S6 kinase alpha, p70 S6K-alpha, p70 S6KA, RPS6KB1, STK14A
Tested Applications
WB, IHC-P
Protein ID
54041234
Physical Properties
Liquid

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