Mouse Abl1 Antibody

• Background:

  Protein kinase that regulates key processes linked to cell growth and survival. Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.

• NCBI Gene ID:

  11350

• Swiss Prot:

  P00520

• Accession Number:

  P00520

• Host:

  Rabbit

• Reactivity:

  Mouse

• Immunogen:

  This Mouse Abl1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 613-641 amino acids from the Central region of mouse Abl1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  123 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  Abl1

• NCBI Official Name:

  Tyrosine-protein kinase ABL1

• NCBI Organism:

  Mus musculus

• Background Reference 01:

  Ko, H.S., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (38) :16691-16696 (2010)

• Background Reference 02:

  Yamaguchi, T., et al. Apoptosis 15 (8) :927-935 (2010)

• Background Reference 03:

  Michael, M., et al. Curr. Biol. 20 (9) :783-791 (2010)

• Background Reference 04:

  Swimm, A.I., et al. J. Virol. 84 (9) :4243-4251 (2010)

• Other Product Names:

  Tyrosine-protein kinase ABL1, Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine-protein kinase 1, Proto-oncogene c-Abl, p150, Abl1, Abl

• Tested Applications:

  WB, IHC-P

• Physical Properties:

  Liquid