Mouse Abl1 Antibody

CAT: 0223-57-346Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-57-346Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Protein kinase that regulates key processes linked to cell growth and survival. Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.
NCBI Gene ID
11350
Swiss Prot
P00520
Accession Number
P00520
Host
Rabbit
Reactivity
Mouse
Immunogen
This Mouse Abl1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 613-641 amino acids from the Central region of mouse Abl1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
123 kDa
Fragment
Rabbit Ig
Symbol
Abl1
NCBI Official Name
Tyrosine-protein kinase ABL1
NCBI Organism
Mus musculus
Background Reference 01
Ko, H.S., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (38) :16691-16696 (2010)
Background Reference 02
Yamaguchi, T., et al. Apoptosis 15 (8) :927-935 (2010)
Background Reference 03
Michael, M., et al. Curr. Biol. 20 (9) :783-791 (2010)
Background Reference 04
Swimm, A.I., et al. J. Virol. 84 (9) :4243-4251 (2010)
Other Product Names
Tyrosine-protein kinase ABL1, Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine-protein kinase 1, Proto-oncogene c-Abl, p150, Abl1, Abl
Tested Applications
WB, IHC-P
Physical Properties
Liquid

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