NPM1 Antibody

• Background:

  NPM1 is a ubiquitously expressed nucleolar protein that shuttles between the nucleus and cytoplasm. It is implicated in multiple functions, including ribosomal protein assembly and transport, control of centrosome duplication, and regulation of the tumor suppressor ARF. NPM1 mutations that relocalize NPM1 from the nucleus into the cytoplasm are associated with development of acute myeloid leukemia.

• NCBI Gene ID:

  4869

• Swiss Prot:

  P06748

• Accession Number:

  P06748

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This NPM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 198-226 amino acids from the C-terminal region of human NPM1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  33 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  NPM1

• NCBI Official Name:

  Nucleophosmin

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Vascotto, C., Mol. Cell. Biol. 29 (7), 1834-1854 (2009) Ma, W., Cancer Biomark (1), 51-58 (2009) Zhang, H., J. Biol. Chem. 279 (34), 35726-35734 (2004)

• Other Product Names:

  Nucleophosmin, NPM, Nucleolar phosphoprotein B23, Nucleolar protein NO38, Numatrin, NPM1, NPM

• Tested Applications:

  WB, IHC-P, IF, Flow

• Protein ID:

  114762

• Physical Properties:

  Liquid