PTGS1 Antibody

• Background:

  Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis.

• NCBI Gene ID:

  5742

• Swiss Prot:

  P23219

• Accession Number:

  P23219

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PTGS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 571-599 amino acids from the C-terminal region of human PTGS1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Immunology, Obesity, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  69 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  PTGS1

• NCBI Official Name:

  Prostaglandin G/H synthase 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Helmersson, J., Prostaglandins Leukot. Essent. Fatty Acids 80 (1), 51-56 (2009) Malkowski, M.G., Science 289 (5486), 1933-1937 (2000)

• Other Product Names:

  Prostaglandin G/H synthase 1, Cyclooxygenase-1, COX-1, Prostaglandin H2 synthase 1, PGH synthase 1, PGHS-1, PHS 1, Prostaglandin-endoperoxide synthase 1, PTGS1, COX1

• Tested Applications:

  WB, IHC-P, IF

• Protein ID:

  317373262

• Physical Properties:

  Liquid