M6PR Antibody

• Background:

  The protein encoded by this gene is a receptor for mannose-6-phosphate groups on lysosomal enzymes. The receptor forms a homodimer or homotetramer for intracellular targeting of lysosomal enzymes and export of newly synthesized lysosomal enzymes into the cell secretions. The receptor is an integral membrane protein which localizes to the trans-Golgi reticulum, endosomes, and the plasma membrane.

• NCBI Gene ID:

  4074

• Swiss Prot:

  P20645

• Accession Number:

  P20645

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This M6PR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 230-260 amino acids from the C-terminal region of human M6PR.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  31 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  M6PR

• NCBI Official Name:

  Cation-dependent mannose-6-phosphate receptor

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bosker, F.J., et al. Mol. Psychiatry (2010) In press :

• Background Reference 02:

  Op den Brouw, M.L., et al. Virology 393 (1) :84-90 (2009)

• Background Reference 03:

  Schimanski, L.M., et al. Blood Cells Mol. Dis. 43 (2) :180-193 (2009)

• Background Reference 04:

  Rodriguez-Gabin, A.G., et al. Exp. Cell Res. 315 (13) :2215-2230 (2009)

• Other Product Names:

  Cation-dependent mannose-6-phosphate receptor, CD Man-6-P receptor, CD-MPR, 46 kDa mannose 6-phosphate receptor, MPR 46, M6PR, MPR46, MPRD

• Tested Applications:

  WB, IF, Flow

• Protein ID:

  127293

• Physical Properties:

  Liquid