GPC4 Antibody

• Background:

  Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome.

• NCBI Gene ID:

  2239

• Swiss Prot:

  O75487

• Accession Number:

  O75487

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This GPC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 395-422 amino acids from the Central region of human GPC4.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Neuroscience, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  62 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  GPC4

• NCBI Official Name:

  Glypican-4

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Karumanchi, S.A., Mol. Cell (4), 811-822 (2001)

• Background Reference 02:

  Hagihara, K., Dev. Dyn. 219 (3), 353-367 (2000)

• Background Reference 03:

  Veugelers, M., Hum. Mol. Genet. (9), 1321-1328 (2000)

• Background Reference 04:

  Veugelers, M., Genomics 53 (1), 1-11 (1998)

• Other Product Names:

  Glypican-4, K-glypican, Secreted glypican-4, GPC4

• Tested Applications:

  WB

• Physical Properties:

  Liquid