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GPC3 Antibody

CAT: 0223-58-016Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-016Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants.
NCBI Gene ID
2719
Swiss Prot
P51654
Accession Number
P51654
Host
Rabbit
Reactivity
Human
Immunogen
This GPC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 465-494 amino acids from the C-terminal region of human GPC3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
66 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
GPC3
NCBI Official Name
Glypican-3
NCBI Organism
Homo sapiens
Background Reference 01
Lai, J.P., et al. Hepatology 52 (5) :1680-1689 (2010)
Background Reference 02
Sakurai, M., et al. Gynecol. Oncol. 119 (2) :332-336 (2010)
Background Reference 03
Zynger, D.L., et al. Histopathology 56 (6) :750-757 (2010)
Background Reference 04
Davoodi, J., et al. Proteomics 7 (13) :2300-2310 (2007)
Other Product Names
Glypican-3, GTR2-2, Intestinal protein OCI-5, MXR7, Secreted glypican-3, GPC3, OCI5
Tested Applications
WB
Protein ID
1708022
Physical Properties
Liquid

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