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FBL Antibody

CAT: 0223-61-498Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-61-498Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
FBL is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. This protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin.
NCBI Gene ID
2091
Swiss Prot
P22087
Accession Number
P22087
Host
Rabbit
Reactivity
Human
Immunogen
This FBL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 105-135 amino acids from the Central region of human FBL.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
34 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
FBL
NCBI Official Name
RRNA 2'-O-methyltransferase fibrillarin
NCBI Organism
Homo sapiens
Background Reference 01
Amin, M.A., Biochem. Biophys. Res. Commun. 360 (2), 320-326 (2007)
Background Reference 02
Dunphy, J.L., Traffic (6), 661-672 (2007)
Other Product Names
RRNA 2'-O-methyltransferase fibrillarin, 211-, 34 kDa nucleolar scleroderma antigen, Histone-glutamine methyltransferase, FBL, FIB1, FLRN
Tested Applications
WB
Protein ID
14549159
Physical Properties
Liquid

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