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DCX Antibody

CAT: 0223-61-496Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-61-496Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. DCX is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. It contains two doublecortin domains, which bind microtubules. In addition, this protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in the gene encoding DCX are a cause of X-linked lissencephaly.
NCBI Gene ID
1641
Swiss Prot
O43602
Accession Number
O43602
Host
Rabbit
Reactivity
Human
Immunogen
This DCX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-137 amino acids from human DCX.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
49 kDa
Fragment
Rabbit Ig
Symbol
DCX
NCBI Official Name
Neuronal migration protein doublecortin
NCBI Organism
Homo sapiens
Background Reference 01
Leger, P.L., Neurogenetics (2008)
Background Reference 02
Zhang, Y., Biochem. Biophys. Res. Commun. 363 (3), 694-700 (2007)
Other Product Names
Neuronal migration protein doublecortin, Doublin, Lissencephalin-X, Lis-X, DCX, DBCN, LISX
Tested Applications
WB, IHC-P
Physical Properties
Liquid

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