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MBP Antibody

CAT: 0223-61-493Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-61-493Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MBP is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called Golli-MBP) that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.
NCBI Gene ID
4155
Swiss Prot
P02686
Accession Number
P02686
Host
Rabbit
Reactivity
Human
Immunogen
This MBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 177-209 amino acids from human MBP.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
33 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:16000
Symbol
MBP
NCBI Official Name
Myelin basic protein
NCBI Organism
Homo sapiens
Background Reference 01
Kawamura, K., J. Immunol. 181 (5), 3202-3211 (2008)
Background Reference 02
Majava, V., BMC Struct. Biol. 8, 10 (2008)
Background Reference 03
Boylan, K.B., Genomics (1), 16-22 (1990)
Other Product Names
Myelin basic protein, MBP, Myelin A1 protein, Myelin membrane encephalitogenic protein, MBP
Tested Applications
WB
Physical Properties
Liquid

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