DAAM1 Antibody

• Background:

  Functions of the cell cortex, including motility, adhesion, and cytokinesis, are mediated by the reorganization of the actin cytoskeleton and recent evidence suggests a role for the Formin homology (FH) proteins in these processes. DAAM1 contains FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. Wnt/Fz signaling activates the small GTPase Rho, a key regulator of cytoskeleton architecture, to control cell polarity and movement during development. Activation requires Dvl-Rho complex formation, an assembly mediated by DAAM1, which is thought to function as a scaffolding protein.

• NCBI Gene ID:

  23002

• Swiss Prot:

  Q9Y4D1

• Accession Number:

  Q9Y4D1

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This DAAM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1034-1063 amino acids from the C-terminal region of human DAAM1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  123 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  DAAM1

• NCBI Official Name:

  Disheveled-associated activator of morphogenesis 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Liu, W., Proc. Natl. Acad. Sci. U.S.A. 105 (1), 210-215 (2008)

• Background Reference 02:

  Yamashita, M., Genes Cells 12 (11), 1255-1265 (2007)

• Background Reference 03:

  Lu, J., J. Mol. Biol. 369 (5), 1258-1269 (2007)

• Other Product Names:

  Disheveled-associated activator of morphogenesis 1, DAAM1, KIAA0666

• Tested Applications:

  WB, IHC-P

• Protein ID:

  34098767

• Physical Properties:

  Liquid