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DAAM1 Antibody

CAT: 0223-61-449Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-61-449Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Functions of the cell cortex, including motility, adhesion, and cytokinesis, are mediated by the reorganization of the actin cytoskeleton. Recent evidence suggests a role for the Formin homology (FH) proteins in these processes. DAAM1 contains FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. Wnt/Fz signaling activates the small GTPase Rho, a key regulator of cytoskeleton architecture, to control cell polarity and movement during development. Activation requires Dvl-Rho complex formation, an assembly mediated by DAAM1, which is thought to function as a scaffolding protein.
NCBI Gene ID
23002
Swiss Prot
Q9Y4D1
Accession Number
Q9Y4D1
Host
Rabbit
Reactivity
Human
Immunogen
This DAAM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 45-74 amino acids from the N-terminal region of human DAAM1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
123 kDa
Fragment
Rabbit Ig
Symbol
DAAM1
NCBI Official Name
Disheveled-associated activator of morphogenesis 1
NCBI Organism
Homo sapiens
Background Reference 01
Liu, W., Proc. Natl. Acad. Sci. U.S.A. 105 (1), 210-215 (2008)
Background Reference 02
Yamashita, M., Genes Cells 12 (11), 1255-1265 (2007)
Background Reference 03
Lu, J., J. Mol. Biol. 369 (5), 1258-1269 (2007)
Other Product Names
Disheveled-associated activator of morphogenesis 1, DAAM1, KIAA0666
Tested Applications
WB, IHC-P
Protein ID
34098767
Physical Properties
Liquid

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