HERV Antibody

• Background:

  Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. The protein, also known as syncytin, is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. This protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer.

• NCBI Gene ID:

  30816

• Swiss Prot:

  Q9UQF0

• Accession Number:

  Q9UQF0

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This HERV (ERVWE1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 400-429 amino acids from the Central region of human HERV (ERVWE1) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Cell Cycle

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  60 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  ERVW-1

• NCBI Official Name:

  Syncytin-1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Oluwole, S.O., Amyotroph Lateral Scler (2), 67-72 (2007)

• Background Reference 02:

  Gong, R., Cell. Physiol. Biochem. 20 (5), 517-526 (2007)

• Background Reference 03:

  Antony, J.M., AIDS Res. Hum. Retroviruses 22 (12), 1253-1259 (2006)

• Other Product Names:

  Syncytin-1, Endogenous retrovirus group W member 1, Env-W, Envelope polyprotein gPr73, Enverin, HERV-7q Envelope protein, HERV-W envelope protein, HERV-W_7q212 provirus ancestral Env polyprotein, Syncytin, Surface protein, SU, gp50, Transmembrane protein, TM, gp24, ERVW-1, ERVWE1

• Tested Applications:

  WB

• Protein ID:

  47605755

• Physical Properties:

  Liquid