ICMT Antibody

• Background:

  This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing results in two transcript variants encoding different isoforms.

• NCBI Gene ID:

  23463

• Swiss Prot:

  O60725

• Accession Number:

  O60725

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ICMT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 250-284 amino acids from the C-terminal region of human ICMT.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  32 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  ICMT

• NCBI Official Name:

  Protein-S-isoprenylcysteine O-methyltransferase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bergo, M.O., et al., J. Clin. Invest. 113 (4) :539-550 (2004) .

• Background Reference 02:

  Ahmad, M., et al., Arterioscler. Thromb. Vasc. Biol. 22 (5) :759-764 (2002) .

• Background Reference 03:

  Van Dessel, G.A., et al., Int. J. Biochem. Cell Biol. 34 (5) :477-486 (2002) .

• Background Reference 04:

  Dai, Q., et al., J. Biol. Chem. 273 (24) :15030-15034 (1998) .

• Other Product Names:

  Protein-S-isoprenylcysteine O-methyltransferase, Isoprenylcysteine carboxylmethyltransferase, Prenylated protein carboxyl methyltransferase, PPMT, Prenylcysteine carboxyl methyltransferase, pcCMT, ICMT, PCCMT

• Tested Applications:

  WB

• Physical Properties:

  Liquid