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FACL6 Antibody

CAT: 0223-61-419Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-61-419Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
FACL6 is involved in activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. It plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid. FACL6 is expressed predominantly in erythrocyte precursors, in particular in reticulocytes, fetal blood cells derieved from fetal liver, haemopoietic stem cells from cord blood, bone marrow, and brain. Expression is low at earlier stages of erythroid development but is very high in reticulocytes. This protein is involved in myelodysplastic syndrome (MDS) with basophilia, acute myelogenous leukemia (AML) with eosinophilia, and acute eosinophilic leukemia (AEL) . It is characterized by a chromosomal translocation t (5;12) (q31; p13) that involves ETV6 and ACSL6.
NCBI Gene ID
23305
Swiss Prot
Q9UKU0
Accession Number
Q9UKU0
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This FACL6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 240-270 amino acids from the Central region of human FACL6.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
78 kDa
Fragment
Rabbit Ig
Symbol
ACSL6
NCBI Official Name
Long-chain-fatty-acid--CoA ligase 6
NCBI Organism
Homo sapiens
Background Reference 01
Yagasaki, F., et al., Genes Chromosomes Cancer 26 (3) :192-202 (1999) .
Background Reference 02
Nagase, T., et al., DNA Res. 5 (6) :355-364 (1998) .
Background Reference 03
Malhotra, K.T., et al., Biochem. J. 344 Pt 1, 135-143 (1999) .
Other Product Names
Long-chain-fatty-acid--CoA ligase 6, Long-chain acyl-CoA synthetase 6, LACS 6, ACSL6, ACS2, FACL6, KIAA0837, LACS5
Tested Applications
WB, IHC-P
Protein ID
146322303
Physical Properties
Liquid

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