Products for Research Use Only

MARCKS Antibody

CAT: 0223-61-411Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-61-411Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MARCKS is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis.
NCBI Gene ID
4082
Swiss Prot
P29966
Accession Number
P29966
Host
Rabbit
Reactivity
Human
Immunogen
This MARCKS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 241-271 amino acids from the C-terminal region of human MARCKS.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
32 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
MARCKS
NCBI Official Name
Myristoylated alanine-rich C-kinase substrate
NCBI Organism
Homo sapiens
Background Reference 01
Rauch, M.E., et al., J. Biol. Chem. 277 (16) :14068-14076 (2002) .
Background Reference 02
Aderem, A., Biochem. Soc. Trans. 23 (3) :587-591 (1995) .
Background Reference 03
Rao, P.H., et al., Cytogenet. Cell Genet. 66 (4) :272-273 (1994) .
Background Reference 04
Taniguchi, H., et al., J. Biol. Chem. 268 (14) :9960-9963 (1993) .
Other Product Names
Myristoylated alanine-rich C-kinase substrate, MARCKS, Protein kinase C substrate, 80 kDa protein, light chain, 80K-L protein, PKCSL, MARCKS, MACS, PRKCSL
Tested Applications
WB
Protein ID
76803798
Physical Properties
Liquid