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FNTA Antibody

CAT: 0223-61-394Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-61-394Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
FNTA, also known as CAAX farnesyltransferase (FTase), attaches a farnesyl group from farnesyl pyrophosphate to cysteine residues at the fourth position from the C terminus of proteins that end in the so-called CAAX box, where C is cysteine, A is usually but not always an aliphatic amino acid, and X is typically methionine or serine. This type of posttranslational modification provides a mechanism for membrane localization of proteins that lack a transmembrane domain. This enzyme has the remarkable property of farnesylating peptides as short as four residues in length that conform to the CAAX consensus sequence. FNTA is also a specific cytoplasmic interactor of the transforming growth factor-beta and activin type I receptors. It is likely to be a key component of the signaling pathway which involves p21ras, an important substrate for farnesyltransferase.
NCBI Gene ID
2339
Swiss Prot
P49354
Accession Number
P49354
Host
Rabbit
Reactivity
Human
Immunogen
This FNTA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 330-360 amino acids from the C-terminal region of human FNTA.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
44 kDa
Fragment
Rabbit Ig
Symbol
FNTA
NCBI Official Name
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
NCBI Organism
Homo sapiens
Background Reference 01
Wang, T., et al., Science 271 (5252) :1120-1122 (1996) .
Background Reference 02
Zhang, F.L., et al., J. Biol. Chem. 269 (5) :3175-3180 (1994) .
Background Reference 03
Andres, D.A., et al., Genomics 18 (1) :105-112 (1993) .
Background Reference 04
Omer, C.A., et al., Biochemistry 32 (19) :5167-5176 (1993) .
Other Product Names
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha, CAAX farnesyltransferase subunit alpha, FTase-alpha, Ras proteins prenyltransferase subunit alpha, Type I protein geranyl-geranyltransferase subunit alpha, GGTase-I-alpha, FNTA
Tested Applications
WB, IHC-P
Protein ID
1346694
Physical Properties
Liquid

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