GGPS1 Antibody

• Background:

  Geranylgeranyl diphosphate (GGPP) synthase (GGPS) catalyzes the synthesis of GGPP, a molecule responsible for the C20-prenylation of protein and for the regulation of a nuclear hormone receptor. The deduced 300-amino acid human protein contains 5 conserved domains consistent with prenyltransferases. Recombinant GGPS shows enzymatic properties associated with the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. Mouse GGPS is regulated in several tissues in obesity and is induced during adipocyte differentiation. GGPS is increased 5- to 20-fold in skeletal muscle, liver, and fat of ob/ob mice. Western blot analysis detects a 2-fold overexpression of protein in muscle and fat but not in liver. Differentiation of mouse fibroblasts into adipocytes induces GGPS expression more than 20-fold.

• NCBI Gene ID:

  9453

• Swiss Prot:

  O95749

• Accession Number:

  O95749

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This GGPS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 270-300 amino acids from the C-terminal region of human GGPS1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Obesity

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  35 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  GGPS1

• NCBI Official Name:

  Geranylgeranyl pyrophosphate synthase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kainou, T., et al., Biochim. Biophys. Acta 1437 (3) :333-340 (1999) .

• Background Reference 02:

  Kuzuguchi, T., et al., J. Biol. Chem. 274 (9) :5888-5894 (1999) .

• Background Reference 03:

  Ericsson, J., et al., J. Lipid Res. 39 (9) :1731-1739 (1998) .

• Other Product Names:

  Geranylgeranyl pyrophosphate synthase, GGPP synthase, GGPPSase, 251-, (2E,6E) -farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Farnesyltranstransferase, Geranylgeranyl diphosphate synthase, Geranyltranstransferase, GGPS1

• Tested Applications:

  WB, IHC-P

• Physical Properties:

  Liquid