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FDFT1 Antibody

CAT: 0223-61-388Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-61-388Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
FDFT1 catalyzes the first step in the cholesterol biosynthetic pathway, the conversion of trans-farnesyldiphosphate to squalene. The loss of promoter activity and response to sterols for FDFT1 is localized to a 69-bp section positioned 131 bp 5-prime to the transcription start site. Sequence analysis of this region shows that it contains a sterol regulatory element-1 (SRE1) previously identified in other sterol regulated genes and 2 putative NF1 binding sites.
NCBI Gene ID
2222
Swiss Prot
P37268
Accession Number
P37268
Host
Rabbit
Reactivity
Human
Immunogen
This FDFT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 140-170 amino acids from the Central region of human FDFT1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Neuroscience
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
48 kDa
Fragment
Rabbit Ig
Symbol
FDFT1
NCBI Official Name
Squalene synthase
NCBI Organism
Homo sapiens
Background Reference 01
Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99 (26) :16899-16903 (2002) .
Background Reference 02
Soltis, D.A., et al., Arch. Biochem. Biophys. 316 (2) :713-723 (1995) .
Background Reference 03
Jiang, G., et al., J. Biol. Chem. 268 (17) :12818-12824 (1993) .
Background Reference 04
Robinson, G.W., et al., Mol. Cell. Biol. 13 (5) :2706-2717 (1993) .
Other Product Names
Squalene synthase, SQS, SS, FPP:FPP farnesyltransferase, Farnesyl-diphosphate farnesyltransferase, FDFT1
Tested Applications
WB, IHC-P
Protein ID
585126
Physical Properties
Liquid

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