FDFT1 Antibody

• Background :

  FDFT1 catalyzes the first step in the cholesterol biosynthetic pathway, the conversion of trans-farnesyldiphosphate to squalene. The loss of promoter activity and response to sterols for FDFT1 is localized to a 69-bp section positioned 131 bp 5-prime to the transcription start site. Sequence analysis of this region shows that it contains a sterol regulatory element-1 (SRE1) previously identified in other sterol regulated genes and 2 putative NF1 binding sites.

• NCBI Gene ID :

  2222

• Swiss Prot :

  P37268

• Accession Number :

  P37268

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This FDFT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 140-170 amino acids from the Central region of human FDFT1.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Obesity, Neuroscience

• Purification :

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  48 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  FDFT1

• NCBI Official Name :

  Squalene synthase

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99 (26) :16899-16903 (2002) .

• Background Reference 02 :

  Soltis, D.A., et al., Arch. Biochem. Biophys. 316 (2) :713-723 (1995) .

• Background Reference 03 :

  Jiang, G., et al., J. Biol. Chem. 268 (17) :12818-12824 (1993) .

• Background Reference 04 :

  Robinson, G.W., et al., Mol. Cell. Biol. 13 (5) :2706-2717 (1993) .

• Other Product Names :

  Squalene synthase, SQS, SS, FPP:FPP farnesyltransferase, Farnesyl-diphosphate farnesyltransferase, FDFT1

• Tested Applications :

  WB, IHC-P

• Protein ID :

  585126

• Physical Properties :

  Liquid