FDFT1 Antibody

• Background:

  FDFT1 catalyzes the first step in the cholesterol biosynthetic pathway, the conversion of trans-farnesyldiphosphate to squalene. The loss of promoter activity and response to sterols for FDFT1 is localized to a 69-bp section positioned 131 bp 5-prime to the transcription start site. Sequence analysis of this region shows that it contains a sterol regulatory element-1 (SRE1) previously identified in other sterol regulated genes and 2 putative NF1 binding sites.

• NCBI Gene ID:

  2222

• Swiss Prot:

  P37268

• Accession Number:

  P37268

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This FDFT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 140-170 amino acids from the Central region of human FDFT1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Obesity, Neuroscience

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  48 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  FDFT1

• NCBI Official Name:

  Squalene synthase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99 (26) :16899-16903 (2002) .

• Background Reference 02:

  Soltis, D.A., et al., Arch. Biochem. Biophys. 316 (2) :713-723 (1995) .

• Background Reference 03:

  Jiang, G., et al., J. Biol. Chem. 268 (17) :12818-12824 (1993) .

• Background Reference 04:

  Robinson, G.W., et al., Mol. Cell. Biol. 13 (5) :2706-2717 (1993) .

• Other Product Names:

  Squalene synthase, SQS, SS, FPP:FPP farnesyltransferase, Farnesyl-diphosphate farnesyltransferase, FDFT1

• Tested Applications:

  WB, IHC-P

• Protein ID:

  585126

• Physical Properties:

  Liquid