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ARL3 Antibody

CAT: 0223-61-365Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-61-365Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ADP-ribosylation factors (ARFs) are low molecular weight GTP-binding proteins belonging to the RAS superfamily. The predicted 182-amino acid ARL3 (ADP-ribosylation like factor) protein shares 97% amino acid identity with rat ARLl3 and 43% identity with human ARF1. Like the ARFs, ARL3 has a glycine at position 2, the site of N myristoylation, and lacks cysteine residues near the C terminus, which are found in other members of the RAS family. Northern blot analysis detected a 1-kb ARL3 transcript in all tissues tested, with highest expression in heart and lung, and lower expression in brain, liver, kidney, ovary, and testis. A 5.5-kb transcript was also detected in most tissues, with highest expression in brain. Immunoblot analysis detected ARL3 in human tumor cell lines but not in normal rodent cells. Although ARL3 binds GTP, it is devoid of activity in the cholera toxin-dependent ADP-ribosylation of Gs, and is therefore classified as an ARF-like protein.
NCBI Gene ID
403
Swiss Prot
P36405
Accession Number
P36405
Host
Rabbit
Reactivity
Human
Immunogen
This ARL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 144-173 amino acids from the C-terminal region of human ARL3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
20 kDa
Fragment
Rabbit Ig
Symbol
ARL3
NCBI Official Name
ADP-ribosylation factor-like protein 3
NCBI Organism
Homo sapiens
Background Reference 01
Cavenagh, M.M., et al., J. Biol. Chem. 269 (29) :18937-18942 (1994) .
Background Reference 02
Adams, M.D., et al., Nature 377 (6547 Suppl), 3-174 (1995) .
Background Reference 03
Kim, H.S., Cytogenet. Cell Genet. 83 (3-4), 246 (1998) .
Background Reference 04
Wistow, G., et al., Mol. Vis. 8, 196-204 (2002) .
Other Product Names
ADP-ribosylation factor-like protein 3, ARL3, ARFL3
Tested Applications
WB, IHC-P
Protein ID
543851
Physical Properties
Liquid

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