BCDIN3D Antibody

• Background:

  O-methyltransferase that specifically dimethylates the 5' monophosphate of pre-miRNAs, acting as a negative regulator of miRNA processing. The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Able to mediate methylation of pre-miR-145, as well as other pre- miRNAs.

• NCBI Gene ID:

  144233

• Swiss Prot:

  Q7Z5W3

• Accession Number:

  Q7Z5W3

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This BCDIN3D antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 243-276 amino acids from human BCDIN3D.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  33 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000-2000

• Symbol:

  BCDIN3D

• NCBI Official Name:

  Pre-miRNA 5'-monophosphate methyltransferase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ota T., et al.Nat. Genet. 36:40-45 (2004) .

• Background Reference 02:

  Mural R.J., et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

• Background Reference 03:

  Xhemalce B., et al.Cell 151:278-288 (2012) .

• Other Product Names:

  Pre-miRNA 5'-monophosphate methyltransferase, 2.1.1.-, BCDIN3 domain-containing protein, BCDIN3D

• Tested Applications:

  WB

• Protein ID:

  74738762

• Physical Properties:

  Liquid