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KLB Antibody

CAT: 0223-61-275Size: 200 µLDry Ice: NoHazardous: No
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CAT#:0223-61-275Size:200 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity) .
NCBI Gene ID
152831
Swiss Prot
Q86Z14
Accession Number
Q86Z14
Host
Rabbit
Reactivity
Human
Immunogen
This KLB antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1-29 amino acids from human KLB.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
120 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:2000
Symbol
KLB
NCBI Official Name
Beta-klotho
NCBI Organism
Homo sapiens
Background Reference 01
Hayashi A., et al.Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
Background Reference 02
Wu X., et al.J. Biol. Chem. 283:33304-33309 (2008) .
Background Reference 03
Micanovic R., et al.J. Cell. Physiol. 219:227-234 (2009) .
Other Product Names
Beta-klotho, BKL, BetaKlotho, Klotho beta-like protein, KLB
Tested Applications
WB
Protein ID
74750586
Physical Properties
Liquid

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