MAN1A2 Antibody

• Background:

  Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man (9) GlcNAc (2) to produce Man (5) GlcNAc (2) .

• NCBI Gene ID:

  10905

• Swiss Prot:

  O60476

• Accession Number:

  O60476

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This MAN1A2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 342-373 amino acids from the Central region of human MAN1A2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  73 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:2000

• Symbol:

  MAN1A2

• NCBI Official Name:

  Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Tremblay L.O., et al.Glycobiology 8:585-595 (1998) .

• Background Reference 02:

  Gregory S.G., et al.Nature 441:315-321 (2006) .

• Background Reference 03:

  Bienvenut W.V., et al.Mol. Cell. Proteomics 11:M111.015131-M111.015131 (2012) .

• Background Reference 04:

  Van Damme P., et al.Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454 (2012) .

• Other Product Names:

  Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB, 3.2.1.113, Mannosidase alpha class 1A member 2, Processing alpha-1,2-mannosidase IB, Alpha-1,2-mannosidase IB, MAN1A2, MAN1B

• Tested Applications:

  WB

• Physical Properties:

  Liquid