MAN2A1 Antibody

• Background:

  This gene encodes a protein which is a member of family 38 of the glycosyl hydrolases. The protein is located in the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus.

• NCBI Gene ID:

  4124

• Swiss Prot:

  Q16706

• Accession Number:

  Q16706

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This MAN2A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 456-482 amino acids from the Central region of human MAN2A1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  131 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  MAN2A1

• NCBI Official Name:

  Alpha-mannosidase 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Han, S., et al. Leuk. Res. 34 (10) :1271-1274 (2010)

• Background Reference 02:

  Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

• Background Reference 03:

  Zhou, J.B., et al. Med. Sci. Monit. 16 (6), BR179-BR183 (2010) :

• Background Reference 04:

  Miyagawa, H., et al. Rheumatology (Oxford) 47 (2) :158-164 (2008)

• Other Product Names:

  Alpha-mannosidase 2, Golgi alpha-mannosidase II, AMan II, Man II, Mannosidase alpha class 2A member 1, Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase, MAN2A1, MANA2

• Tested Applications:

  WB, Flow

• Protein ID:

  146345453

• Physical Properties:

  Liquid