PDS5B Antibody

• Background:

  Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells.

• NCBI Gene ID:

  23047

• Swiss Prot:

  Q9NTI5

• Accession Number:

  Q9NTI5

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PDS5B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1197-1228 amino acids from human PDS5B.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  165 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:2000

• Symbol:

  PDS5B

• NCBI Official Name:

  Sister chromatid cohesion protein PDS5 homolog B

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Geck P., et al.J. Steroid Biochem. Mol. Biol. 63:211-218 (1997) .

• Background Reference 02:

  Geck P., et al.J. Steroid Biochem. Mol. Biol. 68:41-50 (1999) .

• Background Reference 03:

  Nagase T., et al.DNA Res. 6:63-70 (1999) .

• Background Reference 04:

  Nakajima D., et al.DNA Res. 9:99-106 (2002) .

• Other Product Names:

  Sister chromatid cohesion protein PDS5 homolog B, Androgen-induced proliferation inhibitor, Androgen-induced prostate proliferative shutoff-associated protein AS3, PDS5B

• Tested Applications:

  WB

• Protein ID:

  74725312

• Physical Properties:

  Liquid