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HGS Antibody

CAT: 0223-61-121Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-61-121Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
HGS is involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. It could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. HGS may concentrate ubiquitinated receptors within clathrin-coated regions. It is involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM. This complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. HGS may contribute to the efficient recruitment of SMADs to the activin receptor complex.
NCBI Gene ID
9146
Swiss Prot
O14964
Accession Number
O14964
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This HGS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 256-286 amino acids from the N-terminal region of human HGS.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
86 kDa
Fragment
Rabbit Ig
Symbol
HGS
NCBI Official Name
Hepatocyte growth factor-regulated tyrosine kinase substrate
NCBI Organism
Homo sapiens
Background Reference 01
Kirk E, et al. Cell Sci. 2006 Nov 15;119 (Pt 22) :4689-701
Background Reference 02
Sasaki Y, et al. Biol Chem. 2001 Aug 10;276 (32) :29943-52.
Background Reference 03
Miura S, et al. Mol Cell Biol. 2000 Dec;20 (24) :9346-55.
Other Product Names
Hepatocyte growth factor-regulated tyrosine kinase substrate, Hrs, Protein pp110, HGS, HRS
Tested Applications
WB, IHC-P
Physical Properties
Liquid

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