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TSG101 Antibody

CAT: 0223-61-117Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-61-117Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
TSG101 belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression.
NCBI Gene ID
7251
Swiss Prot
Q99816
Accession Number
Q99816
Host
Rabbit
Reactivity
Human
Immunogen
This TSG101 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 340-370 amino acids from the C-terminal region of human TSG101.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
44 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
TSG101
NCBI Official Name
Tumor susceptibility gene 101 protein
NCBI Organism
Homo sapiens
Background Reference 01
Favre, M., et al., J. Acquir. Immune Defic. Syndr. 34 (2) :127-133 (2003) .
Background Reference 02
Lu, Q., et al., Proc. Natl. Acad. Sci. U.S.A. 100 (13) :7626-7631 (2003) .
Background Reference 03
Goila-Gaur, R., et al., J. Virol. 77 (11) :6507-6519 (2003) .
Background Reference 04
Blanco, S., et al., FEMS Microbiol. Lett. 221 (2) :151-154 (2003) .
Other Product Names
Tumor susceptibility gene 101 protein, ESCRT-I complex subunit TSG101, TSG101
Tested Applications
WB
Protein ID
9789790
Physical Properties
Liquid

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