USP29 Antibody

CAT: 0223-61-115Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-61-115Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.
NCBI Gene ID
57663
Swiss Prot
Q9HBJ7
Accession Number
Q9HBJ7
Host
Rabbit
Reactivity
Human
Immunogen
This USP29 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 660-690 amino acids from the Central region of human USP29.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
104 kDa
Fragment
Rabbit Ig
Symbol
USP29
NCBI Official Name
Ubiquitin carboxyl-terminal hydrolase 29
NCBI Organism
Homo sapiens
Background Reference 01
Puente, X.S., et al., Nat. Rev. Genet. 4 (7) :544-558 (2003) .
Background Reference 02
Tureci, O., et al., Oncogene 21 (24) :3879-3888 (2002) .
Background Reference 03
Kim, J., et al., Genome Res. 10 (8) :1138-1147 (2000) .
Other Product Names
Ubiquitin carboxyl-terminal hydrolase 29, Deubiquitinating enzyme 29, Ubiquitin thioesterase 29, Ubiquitin-specific-processing protease 29, USP29
Tested Applications
WB, IHC-P
Protein ID
23396891
Physical Properties
Liquid

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