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UCH37 Antibody

CAT: 0223-61-090Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-61-090Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Covalent attachment of the C-terminus of ubiquitin to cellular proteins plays a role in a variety of cellular processes. Ubiquitin C-terminal hydrolysis is catalyzed by deubiquitinating (DUB) enzymes and is necessary for several functions, including liberation of monomeric ubiquitin from the precursors encoded by ubiquitin genes and recycling of ubiquitin monomers. There are 2 distinct families of DUBs, ubiquitin-specific proteases (UBPs) and ubiquitin C-terminal hydrolases (UCHs) . Mayer and Wilkinson (1989) identified 4 distinct UCH activities from bovine thymus. All 4 were thiol proteases and had high-affinity binding sites for ubiquitin. Wilkinson et al. (1989) purified the predominant isozyme, UCHL3, and raised antibodies against it. By screening a human B-cell expression library with the antibodies, the authors isolated cDNAs encoding human UCHL3. Sequence comparisons revealed that the sequence of the predicted 230-amino acid human UCHL3 protein is 54% identical to that of UCHL1.
NCBI Gene ID
51377
Swiss Prot
Q9Y5K5
Accession Number
Q9Y5K5
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This UCH37 (UCHL5) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-87 amino acids from the N-terminal region of human UCH37 (UCHL5) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Pig
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
38 kDa
Fragment
Rabbit Ig
Symbol
UCHL5
NCBI Official Name
Ubiquitin carboxyl-terminal hydrolase isozyme L5
NCBI Organism
Homo sapiens
Background Reference 01
M-P. et al. Proteomics. July; 9 (13) : 3609?622 (2009) .
Background Reference 02
Hu, R.M., et al., Proc. Natl. Acad. Sci. U.S.A. 97 (17) :9543-9548 (2000) .
Background Reference 03
Lai, C.H., et al., Genome Res. 10 (5) :703-713 (2000) .
Other Product Names
Ubiquitin carboxyl-terminal hydrolase isozyme L5, UCH-L5, Ubiquitin C-terminal hydrolase UCH37, Ubiquitin thioesterase L5, UCHL5, UCH37
Tested Applications
WB, IHC-P
Protein ID
108936023
Physical Properties
Liquid

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