GDF11 Antibody

• Background:

  GDF11 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development.

• NCBI Gene ID:

  10220

• Swiss Prot:

  O95390

• Accession Number:

  O95390

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This GDF11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 32-61 amino acids from the N-terminal region of human GDF11.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  45 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  GDF11

• NCBI Official Name:

  Growth/differentiation factor 11

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Lee, S.J., et al., Curr. Opin. Genet. Dev. 9 (5) :604-607 (1999) .

• Background Reference 02:

  McPherron, A.C., et al., Nat. Genet. 22 (3) :260-264 (1999) .

• Background Reference 03:

  Gamer, L.W., et al., Dev. Biol. 208 (1) :222-232 (1999) .

• Background Reference 04:

  Hillier, L.D., et al., Genome Res. 6 (9) :807-828 (1996) .

• Other Product Names:

  Growth/differentiation factor 11, GDF-11, Bone morphogenetic protein 11, BMP-11, GDF11, BMP11

• Tested Applications:

  WB, IHC-P

• Physical Properties:

  Liquid