PSEN2 Antibody

• Background:

  Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein) . Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.

• NCBI Gene ID:

  5664

• Swiss Prot:

  P49810

• Accession Number:

  P49810

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PSEN2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 32-65 amino acids from the N-terminal region of human PSEN2 (Presenilin-2 NTF subunit) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Obesity, Neuroscience

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  50 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  PSEN2

• NCBI Official Name:

  Presenilin-2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Levy-Lahad E., et al.Science 269:973-977 (1995) .

• Background Reference 02:

  Rogaev E.I., et al.Nature 376:775-778 (1995) .

• Background Reference 03:

  Li J., et al.Proc. Natl. Acad. Sci. U.S.A. 92:12180-12184 (1995) .

• Background Reference 04:

  Levy-Lahad E., et al.Genomics 34:198-204 (1996) .

• Other Product Names:

  Presenilin-2, PS-2, 3423-, AD3LP, AD5, E5-1, STM-2, Presenilin-2 NTF subunit, Presenilin-2 CTF subunit, PSEN2, AD4, PS2, PSNL2, STM2

• Tested Applications:

  WB, Flow

• Protein ID:

  1709858

• Physical Properties:

  Liquid