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BBS5 Antibody

CAT: 0223-61-020Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-61-020Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8 (GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.
NCBI Gene ID
129880
Swiss Prot
Q8N3I7
Accession Number
Q8N3I7
Host
Rabbit
Reactivity
Human
Immunogen
This BBS5 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 108-141 amino acids from the Central region of human BBS5.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Monkey, Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
39 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
BBS5
NCBI Official Name
Bardet-Biedl syndrome 5 protein
NCBI Organism
Homo sapiens
Background Reference 01
Li J.B., et al.Cell 117:541-552 (2004) .
Background Reference 02
Bechtel S., et al.BMC Genomics 8:399-399 (2007) .
Background Reference 03
Hillier L.W., et al.Nature 434:724-731 (2005) .
Background Reference 04
Mural R.J., et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Other Product Names
Bardet-Biedl syndrome 5 protein, BBS5
Tested Applications
WB
Protein ID
74750959
Physical Properties
Liquid

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