Mouse Tfap2a Antibody

• Background:

  Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region.

• NCBI Gene ID:

  21418

• Swiss Prot:

  P34056

• Accession Number:

  P34056

• Host:

  Rabbit

• Reactivity:

  Mouse

• Immunogen:

  This mouse Tfap2a antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 134-166 amino acids from the Central region of mouse Tfap2a.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  48 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  Tfap2a

• NCBI Official Name:

  Transcription factor AP-2-alpha

• NCBI Organism:

  Mus musculus

• Background Reference 01:

  Moser M., et al.Nucleic Acids Res. 21:4844-4844 (1993) .

• Background Reference 02:

  Meier P., et al.Dev. Biol. 169:1-14 (1995) .

• Background Reference 03:

  Carninci P., et al.Science 309:1559-1563 (2005) .

• Background Reference 04:

  Mitchell P.J., et al.Genes Dev. 5:105-119 (1991) .

• Other Product Names:

  Transcription factor AP-2-alpha, AP2-alpha, AP-2 transcription factor, Activating enhancer-binding protein 2-alpha, Activator protein 2, AP-2, Tfap2a, Ap2tf, Tcfap2a

• Tested Applications:

  WB

• Physical Properties:

  Liquid