Mouse Tfap2a Antibody

• Background :

  Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region.

• NCBI Gene ID :

  21418

• Swiss Prot :

  P34056

• Accession Number :

  P34056

• Host :

  Rabbit

• Reactivity :

  Mouse

• Immunogen :

  This mouse Tfap2a antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 134-166 amino acids from the Central region of mouse Tfap2a.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Other

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Bovine, Rat

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  48 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:1000

• Symbol :

  Tfap2a

• NCBI Official Name :

  Transcription factor AP-2-alpha

• NCBI Organism :

  Mus musculus

• Background Reference 01 :

  Moser M., et al.Nucleic Acids Res. 21:4844-4844 (1993) .

• Background Reference 02 :

  Meier P., et al.Dev. Biol. 169:1-14 (1995) .

• Background Reference 03 :

  Carninci P., et al.Science 309:1559-1563 (2005) .

• Background Reference 04 :

  Mitchell P.J., et al.Genes Dev. 5:105-119 (1991) .

• Other Product Names :

  Transcription factor AP-2-alpha, AP2-alpha, AP-2 transcription factor, Activating enhancer-binding protein 2-alpha, Activator protein 2, AP-2, Tfap2a, Ap2tf, Tcfap2a

• Tested Applications :

  WB

• Physical Properties :

  Liquid