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PLN Antibody

CAT: 0223-61-011Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-61-011Size:400 µL
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Background
Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca (2+) . Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2 Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.
NCBI Gene ID
5350
Swiss Prot
P26678
Accession Number
P26678
Host
Rabbit
Reactivity
Human
Immunogen
This PLN antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1-22 amino acids from the N-terminal region of human PLN.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Pig, Rabbit, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
6 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PLN
NCBI Official Name
Cardiac phospholamban
NCBI Organism
Homo sapiens
Background Reference 01
Fujii J., et al.J. Biol. Chem. 266:11669-11675 (1991) .
Background Reference 02
Salvatore C.A., et al.Submitted (MAR-1991) to the EMBL/GenBank/DDBJ databases.
Background Reference 03
McTiernan C.F., et al.J. Mol. Cell. Cardiol. 31:679-692 (1999) .
Background Reference 04
Minamisawa S., et al.Biochem. Biophys. Res. Commun. 304:1-4 (2003) .
Other Product Names
Cardiac phospholamban, PLB, PLN, PLB
Tested Applications
WB
Protein ID
130774
Physical Properties
Liquid

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