ECE2 Antibody

• Background:

  Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit beta-amyloid peptide accumulation in brain. May also have methyltransferase activity.

• NCBI Gene ID:

  9718

• Swiss Prot:

  O60344

• Accession Number:

  O60344

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ECE2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 551-579 amino acids from the Central region of human ECE2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  100 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  ECE2

• NCBI Official Name:

  Endothelin-converting enzyme 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Lorenzo M.-N., et al. Biochim. Biophys. Acta 1522:46-52 (2001) .

• Background Reference 02:

  Funke-Kaiser H., et al. Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.

• Background Reference 03:

  Nagase T., et al. DNA Res. 5:31-39 (1998) .

• Background Reference 04:

  Clark H.F., et al. Genome Res. 13:2265-2270 (2003) .

• Other Product Names:

  Endothelin-converting enzyme 2, ECE-2, Methyltransferase-like region, 211-, Endothelin-converting enzyme 2 region, ECE2, KIAA0604

• Tested Applications:

  WB, IHC-P

• Physical Properties:

  Liquid