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RNASE1 Antibody

CAT: 0223-60-936Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-936Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly (C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq].
NCBI Gene ID
6035
Swiss Prot
P07998
Accession Number
P07998
Host
Rabbit
Reactivity
Human
Immunogen
This RNASE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-42 amino acids from the N-terminal region of human RNASE1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
18 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
RNASE1
NCBI Official Name
Ribonuclease pancreatic
NCBI Organism
Homo sapiens
Background Reference 01
D'Alessio, G. Biopolymers 91 (12) :989-994 (2009)
Background Reference 02
Kover, K.E., et al. J. Mol. Biol. 379 (5) :953-965 (2008)
Background Reference 03
Ueki, M., et al. Biochem. Genet. 46 (3-4), 145-153 (2008) :
Background Reference 04
Johnson, R.J., et al. Biochemistry 46 (36) :10308-10316 (2007)
Other Product Names
Ribonuclease pancreatic, HP-RNase, RIB-1, RNase UpI-1, Ribonuclease 1, RNase 1, Ribonuclease A, RNase A, RNASE1, RIB1, RNS1
Tested Applications
WB
Protein ID
1350818
Physical Properties
Liquid

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