UBR1 Antibody

• Background:

  The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome.

• NCBI Gene ID:

  197131

• Swiss Prot:

  Q8IWV7

• Accession Number:

  Q8IWV7

• Host:

  Rabbit

• Reactivity:

  Mouse

• Immunogen:

  This UBR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 245-274 amino acids from the N-terminal region of human UBR1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  200 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  UBR1

• NCBI Official Name:

  E3 ubiquitin-protein ligase UBR1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Elting, M., et al. Am. J. Med. Genet.146A (23), 3058-3061 (2008) :

• Background Reference 02:

  Alkhouri, N., et al. World J. Gastroenterol. 14 (44) :6863-6866 (2008)

• Background Reference 03:

  Yamaguchi, Y., et al. BMC Med. Genet. 9, 22 (2008) :

• Background Reference 04:

  Schmidt, R.L., et al. Cancer Res. 67 (24) :11798-11810 (2007)

• Other Product Names:

  E3 ubiquitin-protein ligase UBR1, 632-, N-recognin-1, Ubiquitin-protein ligase E3-alpha-1, Ubiquitin-protein ligase E3-alpha-I, UBR1

• Tested Applications:

  WB

• Protein ID:

  73622071

• Physical Properties:

  Liquid