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UBR1 Antibody

CAT: 0223-60-918Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-918Size:400 µL
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Background
The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome.
NCBI Gene ID
197131
Swiss Prot
Q8IWV7
Accession Number
Q8IWV7
Host
Rabbit
Reactivity
Mouse
Immunogen
This UBR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 245-274 amino acids from the N-terminal region of human UBR1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
200 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
UBR1
NCBI Official Name
E3 ubiquitin-protein ligase UBR1
NCBI Organism
Homo sapiens
Background Reference 01
Elting, M., et al. Am. J. Med. Genet.146A (23), 3058-3061 (2008) :
Background Reference 02
Alkhouri, N., et al. World J. Gastroenterol. 14 (44) :6863-6866 (2008)
Background Reference 03
Yamaguchi, Y., et al. BMC Med. Genet. 9, 22 (2008) :
Background Reference 04
Schmidt, R.L., et al. Cancer Res. 67 (24) :11798-11810 (2007)
Other Product Names
E3 ubiquitin-protein ligase UBR1, 632-, N-recognin-1, Ubiquitin-protein ligase E3-alpha-1, Ubiquitin-protein ligase E3-alpha-I, UBR1
Tested Applications
WB
Protein ID
73622071
Physical Properties
Liquid

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