ISCU Antibody

• Background:

  Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins. They contain sulfur and iron, and are created via several steps that include cysteine desulfurases, iron donors, chaperones, and scaffold proteins. This gene encodes the two isomeric forms, ISCU1 and ISCU2, of the Fe-S cluster scaffold protein. Mutations in this gene have been found in patients with myopathy with severe exercise intolerance and myoglobinuria.

• NCBI Gene ID:

  23479

• Swiss Prot:

  Q9H1K1

• Accession Number:

  Q9H1K1

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This ISCU antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-167 amino acids from the C-terminal region of human ISCU.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  18 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  ISCU

• NCBI Official Name:

  Iron-sulfur cluster assembly enzyme ISCU, mitochondrial

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Chen, Z., et al. Oncogene 29 (30) :4362-4368 (2010)

• Background Reference 02:

  Chan, S.Y., et al. Cell Metab. 10 (4) :273-284 (2009)

• Background Reference 03:

  Kollberg, G., et al. Brain 132 (PT 8), 2170-2179 (2009) :

• Background Reference 04:

  Huang, J., et al. J. Biol. Inorg. Chem. 13 (5) :825-836 (2008)

• Other Product Names:

  Iron-sulfur cluster assembly enzyme ISCU, mitochondrial, NifU-like N-terminal domain-containing protein, NifU-like protein, ISCU, NIFUN

• Tested Applications:

  WB

• Protein ID:

  313104118

• Physical Properties:

  Liquid