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ISCU Antibody

CAT: 0223-60-893Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-893Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins. They contain sulfur and iron, and are created via several steps that include cysteine desulfurases, iron donors, chaperones, and scaffold proteins. This gene encodes the two isomeric forms, ISCU1 and ISCU2, of the Fe-S cluster scaffold protein. Mutations in this gene have been found in patients with myopathy with severe exercise intolerance and myoglobinuria.
NCBI Gene ID
23479
Swiss Prot
Q9H1K1
Accession Number
Q9H1K1
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This ISCU antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-167 amino acids from the C-terminal region of human ISCU.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
18 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
ISCU
NCBI Official Name
Iron-sulfur cluster assembly enzyme ISCU, mitochondrial
NCBI Organism
Homo sapiens
Background Reference 01
Chen, Z., et al. Oncogene 29 (30) :4362-4368 (2010)
Background Reference 02
Chan, S.Y., et al. Cell Metab. 10 (4) :273-284 (2009)
Background Reference 03
Kollberg, G., et al. Brain 132 (PT 8), 2170-2179 (2009) :
Background Reference 04
Huang, J., et al. J. Biol. Inorg. Chem. 13 (5) :825-836 (2008)
Other Product Names
Iron-sulfur cluster assembly enzyme ISCU, mitochondrial, NifU-like N-terminal domain-containing protein, NifU-like protein, ISCU, NIFUN
Tested Applications
WB
Protein ID
313104118
Physical Properties
Liquid

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