CDKN3 Antibody

CAT: 0223-60-846Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-60-846Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
1033
Swiss Prot
Q16667
Accession Number
Q16667
Host
Rabbit
Reactivity
Human
Immunogen
This CDKN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-68 amino acids from the N-terminal region of human CDKN3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
24 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
CDKN3
NCBI Official Name
Cyclin-dependent kinase inhibitor 3
NCBI Organism
Homo sapiens
Background Reference 01
Shimada, M., et al. Hum. Genet. 128 (4) :433-441 (2010)
Background Reference 02
Jiang, R., et al. Int. J. Cancer 126 (5) :1263-1274 (2010)
Background Reference 03
Okamoto, K., et al. Biochem. Biophys. Res. Commun. 351 (1) :216-222 (2006)
Background Reference 04
Hsieh, M.J., et al. Biochem. Biophys. Res. Commun. 349 (2) :573-581 (2006)
Other Product Names
Cyclin-dependent kinase inhibitor 3, CDK2-associated dual-specificity phosphatase, Cyclin-dependent kinase interactor 1, Cyclin-dependent kinase-interacting protein 2, Kinase-associated phosphatase, CDKN3, CDI1, CIP2, KAP
Tested Applications
WB
Protein ID
2499769
Physical Properties
Liquid

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