CDKN3 Antibody

• Background:

  The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID:

  1033

• Swiss Prot:

  Q16667

• Accession Number:

  Q16667

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CDKN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-68 amino acids from the N-terminal region of human CDKN3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  24 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  CDKN3

• NCBI Official Name:

  Cyclin-dependent kinase inhibitor 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Shimada, M., et al. Hum. Genet. 128 (4) :433-441 (2010)

• Background Reference 02:

  Jiang, R., et al. Int. J. Cancer 126 (5) :1263-1274 (2010)

• Background Reference 03:

  Okamoto, K., et al. Biochem. Biophys. Res. Commun. 351 (1) :216-222 (2006)

• Background Reference 04:

  Hsieh, M.J., et al. Biochem. Biophys. Res. Commun. 349 (2) :573-581 (2006)

• Other Product Names:

  Cyclin-dependent kinase inhibitor 3, CDK2-associated dual-specificity phosphatase, Cyclin-dependent kinase interactor 1, Cyclin-dependent kinase-interacting protein 2, Kinase-associated phosphatase, CDKN3, CDI1, CIP2, KAP

• Tested Applications:

  WB

• Protein ID:

  2499769

• Physical Properties:

  Liquid