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ATP1A3 Antibody

CAT: 0223-60-827Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-827Size:400 µL
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Background
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta) . The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit.
NCBI Gene ID
478
Swiss Prot
P13637
Accession Number
P13637
Host
Rabbit
Reactivity
Human
Immunogen
This ATP1A3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 805-833 amino acids from the Central region of human ATP1A3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Chicken, Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
112 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
ATP1A3
NCBI Official Name
Sodium/potassium-transporting ATPase subunit alpha-3
NCBI Organism
Homo sapiens
Background Reference 01
Einholm, A.P., et al. J. Biol. Chem. 285 (34) :26245-26254 (2010)
Background Reference 02
Floyd, R.V., et al. Reprod Sci 17 (4) :366-376 (2010)
Background Reference 03
Hauck, C., et al. Eur. J. Pharmacol. 622 (1-3), 7-14 (2009) :
Background Reference 04
Blanco-Arias, P., et al. Hum. Mol. Genet. 18 (13) :2370-2377 (2009)
Other Product Names
Sodium/potassium-transporting ATPase subunit alpha-3, Na (+) /K (+) ATPase alpha-3 subunit, Na (+) /K (+) ATPase alpha (III) subunit, Sodium pump subunit alpha-3, ATP1A3
Tested Applications
WB
Protein ID
116241260
Physical Properties
Liquid

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